I ran them on my Ram 1500 in 295/65R20 E load and I have 37x12.50R18 E loads on the 2500 ZR2.
In the Ram, I was getting a solid 50+ kmi out of a set of them. I drive pretty conservatively but never had any issues in the rain unless I put my foot it and broke the tires loose. In NC, and most of my driving is within a few hundred miles, so very little snow/below freezing use. I did run from central NC to East TN at least once a month during the last several years, and that run on I40 west of Ashville is about the best high speed test of tires, and never had issues maintaining my usual 5 over.